Mouse expression


The effects of malaria infection on expression levels (mRNA and protein) of cytokines, chemokines, enzymes, adhesion molecules, angiogenic and coagulation factors, metabolic molecules, etc. in different organs and body fluids of mice infected with different rodent malaria species are listed in this part of the database. For each molecule, information about the genetic background of the mouse strain, parasite species, inoculum size (pRBC), references (Refs), and a hyperlink to the original paper in the PubMed database (U.S. National Library of Medicine, National Institutes of Health) is included.

Dynamic fields: these are the columns that you can select to show in the output table. See also "How to use MalarImDB?" for more information.

Abbreviations: A, activity; ND, not detectable; N.I., not indicated; ns, not significant; ↑d, increased levels on day x (example1: ↑d4-8: levels increase from day 4 postinfection until day 8 postinfection; example2: ↑d4-…: levels increase from day 4 postinfection until end of observation time; example3: ↑d4, d8: levels are increased on day 4 postinfection and on day 8 postinfection)↓, decreased levels; →, similar levels (no changes)

 

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Full
Molecular group
Molecule/Cell
Plasmodium strain
pRBC infection titer
Mouse genetic background (Con)
Spleen mRNA
Spleen Protein
Liver mRNA
Liver protein
Brain mRNA
Brain protein
Lung mRNA
Lung protein
Kidney mRNA
Kidney protein
Heart protein
Pancreas protein
Mesentery protein
Thymus protein
Serum/plasma protein
Refs
PubMed
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Full Molecule/Cell Plasmodium strain Mouse genetic background (Con) Spleen mRNA Spleen Protein Liver mRNA Liver protein Brain mRNA Brain protein Lung mRNA Lung protein Kidney mRNA Kidney protein Serum/plasma protein Refs PubMed
2-oxoglutarate dehydrogenase Plasmodium berghei ANKA CBA/T6 ↑d6-7 Rae et al., 2004, FASEB J Link
2-oxoglutarate dehydrogenase Plasmodium berghei K173 CBA/T6 ↑d2-11 Rae et al., 2004, FASEB J Link
3-hydroxy-kynurenine (3-OHKyn) Plasmodium berghei ANKA CBA/T6 ↑d6-7 Sanni et al., 1998, Am J Pathol Link
3-hydroxy-kynurenine (3-OHKyn) Plasmodium berghei K173 CBA/T6 ↑d13-17 Sanni et al., 1998, Am J Pathol Link
5-Hydroxytryptamine (5-HT, serotonin) Plasmodium berghei (N.I.) Albino ↓d N.I. (40-50% par) Roy et al., 1993, Indian J Malariol Link
5-lipoxygenase Plasmodium berghei ANKA CBA → Ball et al., 2004, J Infect Dis Link
5-lipoxygenase Plasmodium berghei ANKA ICR → → Xiao et al., 1999, Am J Trop Med Hyg Link
5-lipoxygenase Plasmodium berghei K173 C57BL/6 ↑d14 Ball et al., 2004, J Infect Dis Link
5-lipoxygenase activating protein (FLAP) Plasmodium berghei ANKA CBA ↑d6 Ball et al., 2004, J Infect Dis Link
5-lipoxygenase activating protein (FLAP) Plasmodium berghei K173 C57BL/6 ↑d14 Ball et al., 2004, J Infect Dis Link
ADMA Plasmodium berghei ANKA C57BL/6 ↓d4-6 Gramaglia et al., 2006, Nat Med Link
Alanine Plasmodium berghei ANKA C57BL/6 → Chang et al., 2001, Infect Immun Link
Alanine Plasmodium berghei ANKA C57BL/6 ↓d6-7 (#) Parekh et al., 2006, Int J Parasitol Link
Alanine aminotransferase (ALT) Plasmodium berghei ANKA CBA/T6 → Rae et al., 2004, FASEB J Link
Alanine aminotransferase (ALT) Plasmodium berghei K173 CBA/T6 ↑d4-7 Rae et al., 2004, FASEB J Link
Alanine aminotransferase (ALT) Plasmodium berghei NK65 C57BL/6 ↑d7 Yoshimoto et al., 1998, J Immunol Link
Alanine aminotransferase (ALT) Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 ↑d8 Delic et al., 2010, Infect Immun Link
Alanine aminotransferase (ALT) Plasmodium chabaudi chabaudi AS C57BL/6 ↑d10 Labbé et al., 2010, J Immunol Link
Ammonia Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 ↑d8 Delic et al., 2010, Infect Immun Link
Anthranilic acid Plasmodium berghei ANKA C57BL/6J → Clark et al., 2005, Infect Immun Link
Arginine Plasmodium berghei ANKA C57BL/6 ↓d4-6 Gramaglia et al., 2006, Nat Med Link
Aspartate Plasmodium berghei ANKA C57BL/6 → Chang et al., 2001, Infect Immun Link
Aspartate Plasmodium berghei ANKA C57BL/6 → Parekh et al., 2006, Int J Parasitol Link
Aspartate Plasmodium berghei ANKA CBA/T6 ↓d7 Sanni et al., 1998, Am J Pathol Link
Aspartate Plasmodium berghei K173 CBA/T6 ↓d19 Sanni et al., 1998, Am J Pathol Link
Aspartate aminotransferase (AST) Plasmodium berghei ANKA CBA/T6 ↓d3-7 Rae et al., 2004, FASEB J Link
Aspartate aminotransferase (AST) Plasmodium berghei K173 CBA/T6 → Rae et al., 2004, FASEB J Link
Aspartate aminotransferase (AST) Plasmodium berghei NK65 C57BL/6 ↑d7 Yoshimoto et al., 1998, J Immunol Link
Aspartate aminotransferase (AST) Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 ↑d8 Delic et al., 2010, Infect Immun Link
Aspartate aminotransferase (AST) Plasmodium chabaudi chabaudi AS DBA/2 ↑ Seixas et al., 2009, Proc Natl Acad Sci U S A Link
Bax Plasmodium berghei ANKA Swiss ↑d14-16 Kumar et al., 2002, Neurosci Lett Link
Bcl-xl Plasmodium chabaudi chabaudi AS C57BL/6 ↑d7 Labbé et al., 2010, J Immunol Link
Bcl2 Plasmodium berghei ANKA Swiss ↑d14-16 Kumar et al., 2002, Neurosci Lett Link
Bicarbonate (HCO3-) Plasmodium berghei ANKA C57BL/6 ↓d6 Chang et al., 2001, Infect Immun Link
Bicyclo-PGE2 Plasmodium berghei ANKA CBA ↑d5 Ball et al., 2004, J Infect Dis Link
Bile acids Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 → Delic et al., 2010, Infect Immun Link
Bilirubin Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 ↑d8 Delic et al., 2010, Infect Immun Link
c-fos Plasmodium berghei ANKA CBA/T6 ↑d3-7 Ma et al., 1997, J Infect Dis Link
c-fos Plasmodium berghei K173 CBA/T6 ↑d19 Ma et al., 1997, J Infect Dis Link
C1q Plasmodium berghei ANKA C57BL/6J ↑d5-7 ↓d5-7 Lackner et al., 2008, Malar J Link
C3 Plasmodium berghei ANKA C57BL/6J → → Lackner et al., 2008, Malar J Link
C5 Plasmodium berghei ANKA C57BL/6J ↑d5-7 → Lackner et al., 2008, Malar J Link
C5a Plasmodium berghei ANKA A/J → Patel et al., 2008, J Exp Med Link
C5a Plasmodium berghei ANKA BALB/c ↑d5 Patel et al., 2008, J Exp Med Link
C5a Plasmodium berghei ANKA C57BL/6 ↑d1-6 Patel et al., 2008, J Exp Med Link
Calpastatin Plasmodium berghei ANKA Swiss ↑d16 Shukla et al., 2006, Neurochem Int Link
Caspase-1 Plasmodium berghei ANKA C57BL/6J ↑d8 Wiese et al., 2008, Malar J Link
Caspase-12 Plasmodium berghei ANKA C57BL/6 ↑d10 Labbé et al., 2010, J Immunol Link
Caspase-3 Plasmodium berghei ANKA C57BL/6 ↑d5-7 Potter et al., 2006, Int J Parasitol Link
Caspase-3 Plasmodium berghei ANKA C57BL/6J → Wiese et al., 2008, Malar J Link
CCL1 (TCA3, I-309) Plasmodium berghei ANKA C57BL/6 ↓d8 ↑d8 Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CCL1 (TCA3, I-309) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCL1 (TCA3, I-309) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CCL11 (eotaxin) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCL11 (eotaxin) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CCL12 (MCP-5) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCL12 (MCP-5) Plasmodium berghei K173 CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCL17 (TARC) Plasmodium berghei ANKA C57BL/6 ↓d8 → Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CCL17 (TARC) Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CCL17 (TARC) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CCL19 (ELC) Plasmodium berghei ANKA C57BL/6 ↓d8 → Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CCL19 (ELC) Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CCL19 (ELC) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CCL2 (MCP-1, JE) Plasmodium berghei ANKA BALB/c ↑d1, d6-8 ↑d6-8 ↑d1, d8 Hanum et al., 2003, Int Immunol Link
CCL2 (MCP-1, JE) Plasmodium berghei ANKA BALB/c ↑d6-8 Van den steen et al., 2008, Eur J Immunol Link
CCL2 (MCP-1, JE) Plasmodium berghei ANKA C57BL/6 ↑d10 Labbé et al., 2010, J Immunol Link
CCL2 (MCP-1, JE) Plasmodium berghei ANKA C57BL/6 ↑d5 Higgins et al., 2013, Malar J Link
CCL2 (MCP-1, JE) Plasmodium berghei ANKA C57BL/6 ↑d5 Beghdadi et al., 2008, J Exp Med Link
CCL2 (MCP-1, JE) Plasmodium berghei ANKA C57BL/6 ↑d6-8 ↑d6-8 Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CCL2 (MCP-1, JE) Plasmodium berghei ANKA C57BL/6 ↑d1-4 ↑d1, d8 ↑d6-8 Hanum et al., 2003, Int Immunol Link
CCL2 (MCP-1, JE) Plasmodium berghei ANKA C57BL/6 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CCL2 (MCP-1, JE) Plasmodium berghei ANKA C57BL/6 ↑d5-6 Finney et al., 2009, Am J Trop Med Hyg Link
CCL2 (MCP-1, JE) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCL2 (MCP-1, JE) Plasmodium berghei ANKA DBA/1 ↑d10 Van den steen et al., 2008, Eur J Immunol Link
CCL2 (MCP-1, JE) Plasmodium berghei ANKA DBA/2 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CCL2 (MCP-1, JE) Plasmodium berghei K173 CBA/T6 ↑d6, d14 Miu et al., 2008, J Immunol Link
CCL2 (MCP-1, JE) Plasmodium berghei NK65 C57BL/6 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CCL2 (MCP-1, JE) Plasmodium berghei NK65 C57BL/6J ↑d8-12 Van den steen et al., 2010, Am J Respir Crit Care Med Link
CCL2 (MCP-1, JE) Plasmodium chabaudi chabaudi AS C57BL/6J → Van den steen et al., 2010, Am J Respir Crit Care Med Link
CCL20 (LARC) Plasmodium berghei ANKA C57BL/6 ↓d8 → Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CCL20 (LARC) Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CCL20 (LARC) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CCL21 (TCA4, SLC) Plasmodium berghei ANKA C57BL/6 ↓d8 → Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CCL21 (TCA4, SLC) Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CCL22 (ABCD-1, MDC) Plasmodium berghei ANKA C57BL/6 ↓d8 → Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CCL22 (ABCD-1, MDC) Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CCL22 (ABCD-1, MDC) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CCL24 (eotaxin-2) Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CCL24 (eotaxin-2) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CCL25 (TECK) Plasmodium berghei ANKA C57BL/6 ↓d8 → Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CCL25 (TECK) Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CCL25 (TECK) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CCL27 (CTACK) Plasmodium berghei ANKA C57BL/6 ↓d8 → Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CCL27 (CTACK) Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CCL27 (CTACK) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CCL3 (MIP-1a) Plasmodium berghei ANKA BALB/c ↑d7 Hansen et al., 2005, Infect Immun Link
CCL3 (MIP-1a) Plasmodium berghei ANKA C57BL/6 → Beghdadi et al., 2008, J Exp Med Link
CCL3 (MIP-1a) Plasmodium berghei ANKA C57BL/6 ↑d6-8 ↑d8 Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CCL3 (MIP-1a) Plasmodium berghei ANKA C57BL/6 ↑d6 Clark et al., 2005, Infect Immun Link
CCL3 (MIP-1a) Plasmodium berghei ANKA C57BL/6 ↑d6 Coban et al., 2007, Int Immunol Link

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