Mouse expression

The effects of malaria infection on expression levels (mRNA and protein) of cytokines, chemokines, enzymes, adhesion molecules, angiogenic and coagulation factors, metabolic molecules, etc. in different organs and body fluids of mice infected with different rodent malaria species are listed in this part of the database. For each molecule, information about the genetic background of the mouse strain, parasite species, inoculum size (pRBC), references (Refs), and a hyperlink to the original paper in the PubMed database (U.S. National Library of Medicine, National Institutes of Health) is included.

Dynamic fields: these are the columns that you can select to show in the output table. See also "How to use MalarImDB?" for more information.

Abbreviations: A, activity; ND, not detectable; N.I., not indicated; ns, not significant; ↑d, increased levels on day x (example1: ↑d4-8: levels increase from day 4 postinfection until day 8 postinfection; example2: ↑d4-…: levels increase from day 4 postinfection until end of observation time; example3: ↑d4, d8: levels are increased on day 4 postinfection and on day 8 postinfection)↓, decreased levels; →, similar levels (no changes)

	Select	Field
	Full
	Molecular group
	Molecule/Cell
	Plasmodium strain
	pRBC infection titer
	Mouse genetic background (Con)
	Spleen mRNA
	Spleen Protein
	Liver mRNA
	Liver protein
	Brain mRNA
	Brain protein
	Lung mRNA
	Lung protein
	Kidney mRNA
	Kidney protein
	Heart protein
	Pancreas protein
	Mesentery protein
	Thymus protein
	Serum/plasma protein
	Refs
	PubMed

Molecule/Cell	Plasmodium strain	Mouse genetic background (Con)	Spleen mRNA	Spleen Protein	Liver mRNA	Brain mRNA	Brain protein	Lung mRNA	Serum/plasma protein	Refs	PubMed
Cleaved a-spectrin (SBDP150)	Plasmodium berghei ANKA	Swiss					↑d16			Shukla et al., 2006, Neurochem Int	Link
Cleaved pro-caspase-3 (in platelets)	Plasmodium berghei ANKA	C57BL/6							↑d8	Piguet et al., 2002, Apoptosis	Link
COX-1	Plasmodium berghei ANKA	CBA				↑d6				Ball et al., 2004, J Infect Dis	Link
COX-1	Plasmodium berghei ANKA	ICR	→			↑d7				Xiao et al., 1999, Am J Trop Med Hyg	Link
COX-1	Plasmodium berghei K173	CBA				↑d14				Ball et al., 2004, J Infect Dis	Link
COX-2	Plasmodium berghei ANKA	CBA				↑d3-6				Ball et al., 2004, J Infect Dis	Link
COX-2	Plasmodium berghei ANKA	ICR	→			↑d7				Xiao et al., 1999, Am J Trop Med Hyg	Link
COX-2	Plasmodium berghei K173	CBA				→				Ball et al., 2004, J Infect Dis	Link
CX3CL1 (neurotactin)	Plasmodium berghei ANKA	CBA/T6				↑d6				Miu et al., 2008, J Immunol	Link
CX3CL1 (neurotactin)	Plasmodium berghei K173	CBA/T6				↑d6				Miu et al., 2008, J Immunol	Link
CX3CR1	Plasmodium berghei ANKA	CBA/T6				→				Miu et al., 2008, J Immunol	Link
CX3CR1	Plasmodium berghei K173	CBA/T6				→				Miu et al., 2008, J Immunol	Link
CXCL1 (GRO-a, KC)	Plasmodium berghei ANKA	C57BL/6							↑d5	Beghdadi et al., 2008, J Exp Med	Link
CXCL1 (GRO-a, KC)	Plasmodium berghei ANKA	C57BL/6							↑d5-6	Finney et al., 2009, Am J Trop Med Hyg	Link
CXCL1 (GRO-a, KC)	Plasmodium berghei ANKA	CBA/T6				↑d6				Miu et al., 2008, J Immunol	Link
CXCL1 (GRO-a, KC)	Plasmodium berghei K173	CBA/T6				↑d14				Miu et al., 2008, J Immunol	Link
CXCL1 (GRO-a, KC)	Plasmodium berghei NK65	C57BL/6J						↑d10-12		Van den steen et al., 2010, Am J Respir Crit Care Med	Link
CXCL1 (GRO-a, KC)	Plasmodium chabaudi chabaudi AS	C57BL/6J						→		Van den steen et al., 2010, Am J Respir Crit Care Med	Link
CXCL10 (IP-10)	Plasmodium berghei ANKA	BALB/c	↑d7							Hansen et al., 2005, Infect Immun	Link
CXCL10 (IP-10)	Plasmodium berghei ANKA	BALB/c	→		↑d1, d6-8	↑d1-8				Hanum et al., 2003, Int Immunol	Link
CXCL10 (IP-10)	Plasmodium berghei ANKA	BALB/c				↑d8	↑d8			Van den steen et al., 2008, Eur J Immunol	Link
CXCL10 (IP-10)	Plasmodium berghei ANKA	C57BL/6	↑d6	↑d6		↑d6-8	↑d6-8			Campanella et al., 2008, Proc Natl Acad Sci U S A	Link
CXCL10 (IP-10)	Plasmodium berghei ANKA	C57BL/6	→		↑d1	↑d1-8				Hanum et al., 2003, Int Immunol	Link
CXCL10 (IP-10)	Plasmodium berghei ANKA	C57BL/6				↑d6				Miu et al., 2008, J Immunol	Link
CXCL10 (IP-10)	Plasmodium berghei ANKA	C57BL/6				↑d6-8	↑d8			Van den steen et al., 2008, Eur J Immunol	Link
CXCL10 (IP-10)	Plasmodium berghei ANKA	C57BL/6J				↑d5	↑d5		↑d5	Morrell et al., 2011, Infect Immun	Link
CXCL10 (IP-10)	Plasmodium berghei ANKA	CBA/T6				↑d6				Miu et al., 2008, J Immunol	Link
CXCL10 (IP-10)	Plasmodium berghei ANKA	DBA/1				↑d10	↑d8			Van den steen et al., 2008, Eur J Immunol	Link
CXCL10 (IP-10)	Plasmodium berghei ANKA	DBA/2				↑d8				Van den steen et al., 2008, Eur J Immunol	Link
CXCL10 (IP-10)	Plasmodium berghei K173	CBA/T6				↑d6, d14				Miu et al., 2008, J Immunol	Link
CXCL10 (IP-10)	Plasmodium berghei NK65	C57BL/6				↑d8				Van den steen et al., 2008, Eur J Immunol	Link
CXCL10 (IP-10)	Plasmodium berghei NK65	C57BL/6J						↑d8-12		Van den steen et al., 2010, Am J Respir Crit Care Med	Link
CXCL10 (IP-10)	Plasmodium chabaudi chabaudi AS	C57BL/6J						↑d8		Van den steen et al., 2010, Am J Respir Crit Care Med	Link
CXCL11 (I-TAC)	Plasmodium berghei ANKA	BALB/c				↑d6-8				Van den steen et al., 2008, Eur J Immunol	Link
CXCL11 (I-TAC)	Plasmodium berghei ANKA	C57BL/6	→			↑d8				Campanella et al., 2008, Proc Natl Acad Sci U S A	Link
CXCL11 (I-TAC)	Plasmodium berghei ANKA	C57BL/6	→			↑d6-8				Van den steen et al., 2008, Eur J Immunol	Link
CXCL11 (I-TAC)	Plasmodium berghei ANKA	CBA/T6				↑d6				Miu et al., 2008, J Immunol	Link
CXCL11 (I-TAC)	Plasmodium berghei ANKA	DBA/1				↑d10				Van den steen et al., 2008, Eur J Immunol	Link
CXCL11 (I-TAC)	Plasmodium berghei ANKA	DBA/2				↑d8				Van den steen et al., 2008, Eur J Immunol	Link
CXCL11 (I-TAC)	Plasmodium berghei K173	CBA/T6				↑d6, d14				Miu et al., 2008, J Immunol	Link
CXCL11 (I-TAC)	Plasmodium berghei NK65	C57BL/6				↑d8				Van den steen et al., 2008, Eur J Immunol	Link
CXCL11 (I-TAC)	Plasmodium berghei NK65	C57BL/6J						↑d8-12		Van den steen et al., 2010, Am J Respir Crit Care Med	Link
CXCL11 (I-TAC)	Plasmodium chabaudi chabaudi AS	C57BL/6J						↑d8		Van den steen et al., 2010, Am J Respir Crit Care Med	Link
CXCL12 (SDF-1)	Plasmodium berghei ANKA	C57BL/6	↓d8			↓d8				Campanella et al., 2008, Proc Natl Acad Sci U S A	Link
CXCL12 (SDF-1)	Plasmodium berghei ANKA	CBA/T6				→				Miu et al., 2008, J Immunol	Link
CXCL12a (SDF-1a)	Plasmodium berghei ANKA	BALB/c				↓d6-8				Van den steen et al., 2008, Eur J Immunol	Link
CXCL12a (SDF-1a)	Plasmodium berghei ANKA	C57BL/6				↓d6-8				Van den steen et al., 2008, Eur J Immunol	Link
CXCL13 (BCL, BCA-1)	Plasmodium berghei ANKA	CBA/T6				↑d6				Miu et al., 2008, J Immunol	Link
CXCL13 (BCL, BCA-1)	Plasmodium berghei K173	CBA/T6				→				Miu et al., 2008, J Immunol	Link
CXCL14 (BRAK)	Plasmodium berghei ANKA	CBA/T6				→				Miu et al., 2008, J Immunol	Link
CXCL14 (BRAK)	Plasmodium berghei K173	CBA/T6				→				Miu et al., 2008, J Immunol	Link
CXCL16	Plasmodium berghei ANKA	C57BL/6	↓d8			↑d8				Campanella et al., 2008, Proc Natl Acad Sci U S A	Link
CXCL16	Plasmodium berghei ANKA	CBA/T6				→				Miu et al., 2008, J Immunol	Link
CXCL16	Plasmodium berghei K173	CBA/T6				→				Miu et al., 2008, J Immunol	Link
CXCL2 (GRO-b, MIP-2)	Plasmodium berghei ANKA	C57BL/6	↑d8			↑d8				Campanella et al., 2008, Proc Natl Acad Sci U S A	Link
CXCL2 (GRO-b, MIP-2)	Plasmodium berghei ANKA	CBA/T6				↑d6				Miu et al., 2008, J Immunol	Link
CXCL2 (GRO-b, MIP-2)	Plasmodium berghei K173	CBA/T6				↑d6,d 14				Miu et al., 2008, J Immunol	Link
CXCL2 (GRO-b, MIP-2)	Plasmodium berghei NK65	C57BL/6J						↑d8-12		Van den steen et al., 2010, Am J Respir Crit Care Med	Link
CXCL2 (GRO-b, MIP-2)	Plasmodium chabaudi chabaudi AS	C57BL/6J						→		Van den steen et al., 2010, Am J Respir Crit Care Med	Link
CXCL4 (PF-4)	Plasmodium berghei ANKA	C57BL/6J					↑d5		↑d4-6	Srivastava et al., 2008, Cell Host Microbe	Link
CXCL4 (PF-4)	Plasmodium berghei ANKA	CBA/T6				→				Miu et al., 2008, J Immunol	Link
CXCL4 (PF-4)	Plasmodium berghei K173	CBA/T6				→				Miu et al., 2008, J Immunol	Link
CXCL5 (ENA-78)	Plasmodium berghei ANKA	CBA/T6				→				Miu et al., 2008, J Immunol	Link
CXCL5 (ENA-78)	Plasmodium berghei K173	CBA/T6				→				Miu et al., 2008, J Immunol	Link
CXCL6 (mGCP-2, LIX)	Plasmodium berghei ANKA	BALB/c				→				Van den steen et al., 2008, Eur J Immunol	Link
CXCL6 (mGCP-2, LIX)	Plasmodium berghei ANKA	C57BL/6	→			→				Campanella et al., 2008, Proc Natl Acad Sci U S A	Link
CXCL6 (mGCP-2, LIX)	Plasmodium berghei ANKA	C57BL/6				→				Van den steen et al., 2008, Eur J Immunol	Link
CXCL6 (mGCP-2, LIX)	Plasmodium berghei NK65	C57BL/6J						→		Van den steen et al., 2010, Am J Respir Crit Care Med	Link
CXCL6 (mGCP-2, LIX)	Plasmodium chabaudi chabaudi AS	C57BL/6J						→		Van den steen et al., 2010, Am J Respir Crit Care Med	Link
CXCL7 (NAP-2)	Plasmodium berghei ANKA	CBA/T6				→				Miu et al., 2008, J Immunol	Link
CXCL7 (NAP-2)	Plasmodium berghei K173	CBA/T6				→				Miu et al., 2008, J Immunol	Link
CXCL9 (MIG)	Plasmodium berghei ANKA	BALB/c	↑d7							Hansen et al., 2005, Infect Immun	Link
CXCL9 (MIG)	Plasmodium berghei ANKA	BALB/c				↑d6-8				Van den steen et al., 2008, Eur J Immunol	Link
CXCL9 (MIG)	Plasmodium berghei ANKA	C57BL/6				↑d6-8				Van den steen et al., 2008, Eur J Immunol	Link
CXCL9 (MIG)	Plasmodium berghei ANKA	C57BL/6J				↑d5	↑d5		↑d5	Morrell et al., 2011, Infect Immun	Link
CXCL9 (MIG)	Plasmodium berghei ANKA	CBA/T6				↑d6				Miu et al., 2008, J Immunol	Link
CXCL9 (MIG)	Plasmodium berghei ANKA	DBA/1				↑d10				Van den steen et al., 2008, Eur J Immunol	Link
CXCL9 (MIG)	Plasmodium berghei ANKA	DBA/2				↑d8				Van den steen et al., 2008, Eur J Immunol	Link
CXCL9 (MIG)	Plasmodium berghei K173	CBA/T6				↑d6, d14				Miu et al., 2008, J Immunol	Link
CXCL9 (MIG)	Plasmodium berghei NK65	C57BL/6				↑d8				Van den steen et al., 2008, Eur J Immunol	Link
CXCR2,4,5,6	Plasmodium berghei ANKA	CBA/T6				→				Miu et al., 2008, J Immunol	Link
CXCR2,4,5,6	Plasmodium berghei K173	CBA/T6				→				Miu et al., 2008, J Immunol	Link
CXCR3	Plasmodium berghei ANKA	C57BL/6J				↑d6				Morrell et al., 2011, Infect Immun	Link
CXCR3	Plasmodium berghei ANKA	CBA/T6				↑d6				Miu et al., 2008, J Immunol	Link
CXCR3	Plasmodium berghei K173	CBA/T6				↑d6				Miu et al., 2008, J Immunol	Link
CYP3A11	Plasmodium chabaudi chabaudi AS	129/SvJ x C57BL/6			ns					Delic et al., 2010, Infect Immun	Link
CYP7A1	Plasmodium chabaudi chabaudi AS	129/SvJ x C57BL/6			↑d8					Delic et al., 2010, Infect Immun	Link
Cytochrome-c (cytosol)	Plasmodium berghei ANKA	Swiss					↑d14-16			Kumar et al., 2002, Neurosci Lett	Link
Cytochrome-c (membrane)	Plasmodium berghei ANKA	Swiss					↓d14-16			Kumar et al., 2002, Neurosci Lett	Link
DARC (FY, CD234)	Plasmodium berghei ANKA	CBA/T6				→				Miu et al., 2008, J Immunol	Link
DARC (FY, CD234)	Plasmodium berghei K173	CBA/T6				→				Miu et al., 2008, J Immunol	Link
dityrosine	Plasmodium berghei ANKA	CBA/T6					→			Sanni et al., 1999, J Infect Dis	Link
dityrosine	Plasmodium berghei K173	CBA/T6					↓d15			Sanni et al., 1999, J Infect Dis	Link
DOPA	Plasmodium berghei ANKA	CBA/T6					→			Sanni et al., 1999, J Infect Dis	Link
DOPA	Plasmodium berghei K173	CBA/T6					↓d15			Sanni et al., 1999, J Infect Dis	Link
Dopamine (DA)	Plasmodium berghei (N.I.)	Albino					→			Roy et al., 1993, Indian J Malariol	Link
Endothelin receptor A (ETA)	Plasmodium berghei ANKA	C57BL/6				↑d5				Machado et al., 2006, Exp Biol Med (Maywood)	Link
Endothelin receptor B (ETB)	Plasmodium berghei ANKA	C57BL/6				↑d5				Machado et al., 2006, Exp Biol Med (Maywood)	Link
Endothelin-1 (Et-1)	Plasmodium berghei ANKA	C57BL/6				↑d5				Machado et al., 2006, Exp Biol Med (Maywood)	Link
Endothelin-converting enzyme (ECE)	Plasmodium berghei ANKA	C57BL/6				↑d5				Machado et al., 2006, Exp Biol Med (Maywood)	Link

Rega Institute for Medical Research

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2-oxoglutarate dehydrogenase
3-hydroxy-kynurenine (3-OHKyn)
5-Hydroxytryptamine (5-HT, serotonin)
5-lipoxygenase
5-lipoxygenase activating protein (FLAP)
ADMA
Alanine
Alanine aminotransferase (ALT)
Ammonia
Anthranilic acid
Arginine
Aspartate
Aspartate aminotransferase (AST)
Bax
Bcl-xl
Bcl2
Bicarbonate (HCO3-)
Bicyclo-PGE2
Bile acids
Bilirubin
c-fos
C1q
C3
C5
C5a
Calpastatin
Caspase-1
Caspase-12
Caspase-3
Caspase-3
CCL1 (TCA3, I-309)
CCL11 (eotaxin)
CCL12 (MCP-5)
CCL17 (TARC)
CCL19 (ELC)
CCL2 (MCP-1, JE)
CCL2 (MCP-1, JE)
CCL20 (LARC)
CCL21 (TCA4, SLC)
CCL22 (ABCD-1, MDC)
CCL24 (eotaxin-2)
CCL25 (TECK)
CCL27 (CTACK)
CCL3 (MIP-1a)
CCL3/4 (MIP-1)
CCL4 (MIP-1b)
CCL5 (RANTES)
CCL6 (MRP-1)
CCL7 (MARC, MCP-3?)
CCL8 (MCP-2?)
CCL9 (MIP-1g)
CCR1
CCR2
CCR3
CCR4
CCR5
CCR6,9,10,11
CCR7,8
CD102 (ICAM-2)
CD106 (VCAM-1)
CD11a/CD18 (LFA-1)
CD31 (PECAM-1)
CD4
CD40
CD40L
CD54 (ICAM-1)
CD62E (E-selectin)
CD62P (P-selectin)
CD8
Cleaved a-spectrin (SBDP150)
Cleaved pro-caspase-3 (in platelets)
COX-1
COX-2
CX3CL1 (neurotactin)
CX3CR1
CXCL1 (GRO-a, KC)
CXCL10 (IP-10)
CXCL11 (I-TAC)
CXCL12 (SDF-1)
CXCL12a (SDF-1a)
CXCL13 (BCL, BCA-1)
CXCL14 (BRAK)
CXCL16
CXCL2 (GRO-b, MIP-2)
CXCL4 (PF-4)
CXCL5 (ENA-78)
CXCL6 (mGCP-2, LIX)
CXCL7 (NAP-2)
CXCL9 (MIG)
CXCR2,4,5,6
CXCR3
CYP3A11
CYP7A1
Cytochrome-c (cytosol)
Cytochrome-c (membrane)
DARC (FY, CD234)
dityrosine
DOPA
Dopamine (DA)
Endothelin receptor A (ETA)
Endothelin receptor B (ETB)
Endothelin-1 (Et-1)
Endothelin-converting enzyme (ECE)
EPO
EPO-R
Factor VII
Fas
FasL
Fibrinogen
Glutamate
Glutamate dehydrogenase
Glutamine synthetase
Glycine
Granzyme B
HIF-1a
Histamine
Histidine de-carboxylase (HDC)
HMGB1
Hmox1/HO-1
HO-2
Homoarginine
Iba1
IFN-g
IFN-g
IFN-g
IFN-g
IFN-g
IFN-g
IFN-g
IFN-g
IFN-g
IFN-gR
IL-10
IL-12
IL-12
IL-12p35
IL-12p40
IL-12p70
IL-18
IL-1a
IL-1b
IL-2
IL-2
IL-3
IL-4
IL-5
IL-6
Indoleamine 2,3-dioxygenase (IDO)
Indoleamine 2,3-dioxygenase-1 (IDO-1)
JNK1/2
Kynurenic acid (KA)
Kynurenine (Kyn)
Lactate
Leukotriene B4
LIGHT
LT-a
LT-b
LT-bR
m-calpain
MadCAM-1
MHC-I
MIF
MIG
MMP-11
MMP-12
MMP-13
MMP-2 (Gelatinase A)
MMP-3
MMP-7
MMP-8
MMP-9 (Gelatinase B)
Monocarboxylate transporter 2 (MCT2)
MRP4
MT1-MMP
MT2-MMP
MT3-MMP
MT4-MMP
MT5-MMP
NF-kB
NO
NO2-
NO3-
Noradrenaline (NA)
NOS2 (iNOS)
NOx
o-tyrosine
p-c-jun
p-JNK
p-MKK4
p53
Parasite-specific IgG
Parasite-specific IgG1
Parasite-specific IgG2a
Parasite-specific IgG2b
Parasite-specific IgG3
Parasite-specific IgM
Perforin
Phospholipase A2 (PLA2)
Picolinic acid (PA)
Pro-caspase-3 (in platelets)
proMMP-9 (Progelatinase B)
Protein carbonyls
QA:KA ratio
Quinolinic acid (QA)
sCD40
sCD54 (sICAM-1)
SDMA
sFLT1 (sVEGFR)
sTNFR1
sTNFR2
SULT2B1
TACE/ADAM-17
Taurine
Tele-methylhistamine (t-MeHA)
TGF-b
TGF-b1
TIMP-1
TIMP-2
TIMP-3
TIMP-4
Tissue factor (TF)
TNF
TNF-a
TNF-a
TNF-a
TNF-a
TNF-a
TNFR1
TNFR2
Total IgG
Total IgM
Tryptophan (Trp)
UGT1A1
Uric acid
VDR
VEGF
vWF
XCL1 (lymphotactin)
XCR1
µ-calpain