Mouse expression


The effects of malaria infection on expression levels (mRNA and protein) of cytokines, chemokines, enzymes, adhesion molecules, angiogenic and coagulation factors, metabolic molecules, etc. in different organs and body fluids of mice infected with different rodent malaria species are listed in this part of the database. For each molecule, information about the genetic background of the mouse strain, parasite species, inoculum size (pRBC), references (Refs), and a hyperlink to the original paper in the PubMed database (U.S. National Library of Medicine, National Institutes of Health) is included.

Dynamic fields: these are the columns that you can select to show in the output table. See also "How to use MalarImDB?" for more information.

Abbreviations: A, activity; ND, not detectable; N.I., not indicated; ns, not significant; ↑d, increased levels on day x (example1: ↑d4-8: levels increase from day 4 postinfection until day 8 postinfection; example2: ↑d4-…: levels increase from day 4 postinfection until end of observation time; example3: ↑d4, d8: levels are increased on day 4 postinfection and on day 8 postinfection)↓, decreased levels; →, similar levels (no changes)

 

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Full
Molecular group
Molecule/Cell
Plasmodium strain
pRBC infection titer
Mouse genetic background (Con)
Spleen mRNA
Spleen Protein
Liver mRNA
Liver protein
Brain mRNA
Brain protein
Lung mRNA
Lung protein
Kidney mRNA
Kidney protein
Heart protein
Pancreas protein
Mesentery protein
Thymus protein
Serum/plasma protein
Refs
PubMed
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Full Molecule/Cell Plasmodium strain Mouse genetic background (Con) Spleen mRNA Spleen Protein Liver mRNA Liver protein Brain mRNA Brain protein Lung mRNA Lung protein Kidney mRNA Kidney protein Serum/plasma protein Refs PubMed
NOS2 (iNOS) Plasmodium chabaudi chabaudi AS BALB/c ND Tsutsui et al., 1999, Infect Immun Link
NOS2 (iNOS) Plasmodium chabaudi chabaudi AS C57BL/10 ↑d6-8 Tsutsui et al., 1999, Infect Immun Link
NOS2 (iNOS) Plasmodium chabaudi chabaudi AS C57BL/6 ↑d7 Ahvazi et al., 1995, J Leukoc Biol Link
NOS2 (iNOS) Plasmodium chabaudi chabaudi AS C57BL/6 ↑d7 Jacobs et al., 1996, Infect Immun Link
NOx Plasmodium chabaudi adami 556KA C57BL/6 ↑d6-14 Van der Heyde et al., 2005, J Immunol Link
NOx Plasmodium chabaudi chabaudi AS BALB/c ND Tsutsui et al., 1999, Infect Immun Link
NOx Plasmodium chabaudi chabaudi AS C57BL/10 ↑d9-11 Tsutsui et al., 1999, Infect Immun Link
o-tyrosine Plasmodium berghei ANKA CBA/T6 → Sanni et al., 1999, J Infect Dis Link
o-tyrosine Plasmodium berghei K173 CBA/T6 ↓d15 Sanni et al., 1999, J Infect Dis Link
p-c-jun Plasmodium berghei ANKA C57BL/6J ↑d7 Anand et al., 2011, Neurosci Lett Link
p-JNK Plasmodium berghei ANKA C57BL/6J ↑d7 Anand et al., 2011, Neurosci Lett Link
p-MKK4 Plasmodium berghei ANKA C57BL/6J ↑d5-7 Anand et al., 2011, Neurosci Lett Link
p53 Plasmodium berghei ANKA Swiss ↑d14-16 Kumar et al., 2002, Neurosci Lett Link
Parasite-specific IgG Plasmodium chabaudi chabaudi AS BALB/c ↑d27-... Seixas et al., 2005, Exp Parasitol Link
Parasite-specific IgG Plasmodium chabaudi chabaudi AS DBA/2 ↑d27 Seixas et al., 2005, Exp Parasitol Link
Parasite-specific IgG1 Plasmodium berghei NK65 BALB/c ↑d11-20 Ishih et al., 2008, Southeast Asian J Trop Med Public Health Link
Parasite-specific IgG2a Plasmodium berghei NK65 BALB/c ↑d11-20 Ishih et al., 2008, Southeast Asian J Trop Med Public Health Link
Parasite-specific IgG2b Plasmodium berghei NK65 BALB/c ↑d11-20 Ishih et al., 2008, Southeast Asian J Trop Med Public Health Link
Parasite-specific IgG3 Plasmodium berghei NK65 BALB/c ↑d11-20 Ishih et al., 2008, Southeast Asian J Trop Med Public Health Link
Parasite-specific IgM Plasmodium chabaudi chabaudi AS BALB/c ↑d4-… Seixas et al., 2005, Exp Parasitol Link
Parasite-specific IgM Plasmodium chabaudi chabaudi AS DBA/2 → Seixas et al., 2005, Exp Parasitol Link
Perforin Plasmodium berghei ANKA C57BL/6 ↑d6 Miu et al., 2008, J Immunol Link
Perforin Plasmodium berghei ANKA C57BL/6 → ↑d5-6 ↑d4-6 Potter et al., 2006, Int J Parasitol Link
Perforin Plasmodium berghei ANKA C57BL/6 → ↑d5-6 Potter et al., 2006, J Neuroimmunol Link
Perforin Plasmodium berghei K173 C57BL/6 → → → Potter et al., 2006, Int J Parasitol Link
Phospholipase A2 (PLA2) Plasmodium berghei ANKA ICR ↑d7-16 → Xiao et al., 1999, Am J Trop Med Hyg Link
Picolinic acid (PA) Plasmodium berghei ANKA C57BL/6J ↑d6 Clark et al., 2005, Infect Immun Link
Picolinic acid (PA) Plasmodium berghei ANKA C57BL/6J ↑ Miu et al., 2009, Int J Parasitol Link
Pro-caspase-3 (in platelets) Plasmodium berghei ANKA C57BL/6 ↓d8 Piguet et al., 2002, Apoptosis Link
proMMP-9 (Progelatinase B) Plasmodium berghei ANKA BALB/c ↑d8 → Van den steen et al., 2006, Lab Invest Link
proMMP-9 (Progelatinase B) Plasmodium berghei ANKA C57BL/6 ↑d6-8 → ND ↑d6-8 → ↑d8 ↑d8 → ↑d8 Van den steen et al., 2006, Lab Invest Link
proMMP-9 (Progelatinase B) Plasmodium berghei NK65 C57BL/6 → ↑d8 Van den steen et al., 2006, Lab Invest Link
Protein carbonyls Plasmodium berghei ANKA CBA/T6 → Sanni et al., 1999, J Infect Dis Link
Protein carbonyls Plasmodium berghei K173 CBA/T6 ↓d14-16 Sanni et al., 1999, J Infect Dis Link
QA:KA ratio Plasmodium berghei ANKA CBA/T6 ↑d6-7 Sanni et al., 1998, Am J Pathol Link
QA:KA ratio Plasmodium berghei K173 CBA/T6 → Sanni et al., 1998, Am J Pathol Link
Quinolinic acid (QA) Plasmodium berghei ANKA C57BL/6J → Clark et al., 2005, Infect Immun Link
Quinolinic acid (QA) Plasmodium berghei ANKA C57BL/6J ↑ Miu et al., 2009, Int J Parasitol Link
Quinolinic acid (QA) Plasmodium berghei ANKA CBA/T6 ↑d6-7 Sanni et al., 1998, Am J Pathol Link
Quinolinic acid (QA) Plasmodium berghei K173 CBA/T6 ↑d13-17 Sanni et al., 1998, Am J Pathol Link
sCD40 Plasmodium berghei ANKA C57BL/6 ↑d6 Gramaglia et al., 2006, Nat Med Link
sCD54 (sICAM-1) Plasmodium berghei ANKA C57BL/6J ↑d5 ↑d5 Morrell et al., 2011, Infect Immun Link
SDMA Plasmodium berghei ANKA C57BL/6 ↓d4-6 Gramaglia et al., 2006, Nat Med Link
sFLT1 (sVEGFR) Plasmodium berghei ANKA DBA/2 →ALI; ↑d7HP Epiphanio et al., 2010, PLoS Pathog Link
sTNFR1 Plasmodium berghei ANKA C57BL/6 x 129 → Lucas et al., 1997, Eur J Immunol Link
sTNFR2 Plasmodium berghei ANKA C57BL/6 x 129 → Lucas et al., 1997, Eur J Immunol Link
SULT2B1 Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 → Delic et al., 2010, Infect Immun Link
TACE/ADAM-17 Plasmodium berghei ANKA BALB/c → Van den steen et al., 2006, Lab Invest Link
TACE/ADAM-17 Plasmodium berghei ANKA C57BL/6 ↑d6 ↑d6 → → → Van den steen et al., 2006, Lab Invest Link
TACE/ADAM-17 Plasmodium berghei NK65 C57BL/6 → Van den steen et al., 2006, Lab Invest Link
Taurine Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 → Delic et al., 2010, Infect Immun Link
Tele-methylhistamine (t-MeHA) Plasmodium berghei ANKA C57BL/6 → Beghdadi et al., 2009, PLoS One Link
TGF-b Plasmodium berghei ANKA BALB/c → ND De Kossodo et al., 1993, J Immunol Link
TGF-b Plasmodium berghei ANKA BALB/c ↑d10-14 Hansen et al., 2005, Infect Immun Link
TGF-b Plasmodium berghei ANKA CBA/J ↓d7 ND De Kossodo et al., 1993, J Immunol Link
TGF-b Plasmodium berghei NK65 BALB/c ↓d14-20 Omer et al., 1998, J Exp Med Link
TGF-b Plasmodium chabaudi chabaudi AS BALB/c → ↑d5-6 Tsutsui et al., 1999, Infect Immun Link
TGF-b Plasmodium chabaudi chabaudi AS C57BL/10 → ↓d7-9 Tsutsui et al., 1999, Infect Immun Link
TGF-b Plasmodium yoelii 17XL C57BL/6 ↑d1-7 Omer et al., 2003, J Immunol Link
TGF-b Plasmodium yoelii 17XNL BALB/c ↑d8-20 Omer et al., 1998, J Exp Med Link
TGF-b Plasmodium yoelii 17XNL C57BL/6 ↑d5-… Omer et al., 2003, J Immunol Link
TGF-b1 Plasmodium berghei ANKA 6653 Swiss Albino → Dogruman-Al et al., 2009, New Microbiol Link
TGF-b1 Plasmodium chabaudi chabaudi A/J BALB/c ↓d3, ↑d8-20 Omer et al., 1998, J Exp Med Link
TIMP-1 Plasmodium berghei ANKA BALB/c ↑d8 Van den steen et al., 2006, Lab Invest Link
TIMP-1 Plasmodium berghei ANKA C57BL/6 ↑d6-8 ↑d6-8 ↑d6-8 Van den steen et al., 2006, Lab Invest Link
TIMP-1 Plasmodium berghei NK65 C57BL/6 ↑d8 Van den steen et al., 2006, Lab Invest Link
TIMP-2 Plasmodium berghei ANKA BALB/c → Van den steen et al., 2006, Lab Invest Link
TIMP-2 Plasmodium berghei ANKA C57BL/6 ND → ND Van den steen et al., 2006, Lab Invest Link
TIMP-2 Plasmodium berghei NK65 C57BL/6 → Van den steen et al., 2006, Lab Invest Link
TIMP-3 Plasmodium berghei ANKA BALB/c → Van den steen et al., 2006, Lab Invest Link
TIMP-3 Plasmodium berghei ANKA C57BL/6 ↑d2-8 ↑d6-8 → Van den steen et al., 2006, Lab Invest Link
TIMP-3 Plasmodium berghei NK65 C57BL/6 → Van den steen et al., 2006, Lab Invest Link
TIMP-4 Plasmodium berghei ANKA BALB/c → Van den steen et al., 2006, Lab Invest Link
TIMP-4 Plasmodium berghei ANKA C57BL/6 ND ND → ND ND Van den steen et al., 2006, Lab Invest Link
TIMP-4 Plasmodium berghei NK65 C57BL/6 → Van den steen et al., 2006, Lab Invest Link
Tissue factor (TF) Plasmodium berghei ANKA C57BL/6 → Van der Heyde et al., 2005, Blood Link
TNF Plasmodium berghei ANKA C57BL/6 ↑d5 Higgins et al., 2013, Malar J Link
TNF-a Plasmodium berghei (N.I.) C57BL/6 ↓d4, ↑d7 Wykes et al., 2007, J Immunol Link
TNF-a Plasmodium berghei ANKA (BALB/c x C57BL/6) F1 ↑d1-15 De Souza et al., 1997, Infect Immun Link
TNF-a Plasmodium berghei ANKA 129Sv/Ev → ↑d7 ↑d7 ↑d7 Amani et al., 2000, Eur J Immunol Link
TNF-a Plasmodium berghei ANKA BALB/c ↑d1 ↑d9 Chen et al., 2000, Clin Exp Immunol Link
TNF-a Plasmodium berghei ANKA BALB/c ↑d7 → De Kossodo et al., 1993, J Immunol Link
TNF-a Plasmodium berghei ANKA BALB/c → Hansen et al., 2003, Immunity Link
TNF-a Plasmodium berghei ANKA BALB/c ↑d1 ↑d6-8 ↑d6-8 Hanum et al., 2003, Int Immunol Link
TNF-a Plasmodium berghei ANKA BALB/c ↑d7 Kossodo et al., 1997, Immunology Link
TNF-a Plasmodium berghei ANKA BALB/c → Grau et al., 1987, Science Link
TNF-a Plasmodium berghei ANKA C57BL/6 ↑d4 Van der Heyde et al., 2005, Blood Link
TNF-a Plasmodium berghei ANKA C57BL/6 ↑d5 Beghdadi et al., 2008, J Exp Med Link
TNF-a Plasmodium berghei ANKA C57BL/6 ↑d8 ↑d8 ↑d8 ↑d7 Favre et al., 1999, Microbes Infect Link
TNF-a Plasmodium berghei ANKA C57BL/6 ↑d3 Hansen et al., 2003, Immunity Link
TNF-a Plasmodium berghei ANKA C57BL/6 ↑d1 ↑d1, d8 ↑d8 Hanum et al., 2003, Int Immunol Link
TNF-a Plasmodium berghei ANKA C57BL/6 ↑d6 Pamplona et al., 2007, Nat Med Link
TNF-a Plasmodium berghei ANKA C57BL/6 ↑d7-8 ↑d7-8 ↑d7-8 Piguet et al., 2002, Lab Invest Link
TNF-a Plasmodium berghei ANKA C57BL/6 ↑d7 ↑d7 ↑d7 ↑d7 Piguet et al., 2001, Am J Pathol Link
TNF-a Plasmodium berghei ANKA C57BL/6 ↑d3 ↑d3-6 Potter et al., 2006, Int J Parasitol Link
TNF-a Plasmodium berghei ANKA C57BL/6 ↑d5 ↑d5 Randall et al., 2008, Infect Immun Link
TNF-a Plasmodium berghei ANKA C57BL/6 ↑d5 Srivastava et al., 2008, Cell Host Microbe Link
TNF-a Plasmodium berghei ANKA C57BL/6 ↑d6 Finney et al., 2009, Am J Trop Med Hyg Link
TNF-a Plasmodium berghei ANKA C57BL/6 ↑d5 De Miranda et al., 2011, Neurosci Lett Link
TNF-a Plasmodium berghei ANKA C57BL/6 ↑d10 Labbé et al., 2010, J Immunol Link

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