Molecular group:
Immune cells
Molecule/Cell:
Microparticle (MP)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/J
Experimental treatment group (EG):
MP formation inhibitor (pantethine)
Lethal infection (Con):
yes
Lethal infection (EG):
60-70% (at the end of observation day 20)
Pathology (Con):
CM (100%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
No neurological symptoms; prolonged survival (1-3 weeks); no↑ in circulating MP; ↓ plasma TNF-a; ↓ dose or treatment for a shorter period led to partial protection; ↓ PS-exposure on platelet and RBC membrane; ↓ platelet binding to fibrinogen after incubation with thrombin; ↓ platelet adhesion to collagen; preserved redox status as observed by ↓ amount of –SH moieties on the platelet membrane
Refs:
Penet et al., 2008, Proc Natl Acad Sci U S A
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