Molecular group:
Immune cells
Molecule/Cell:
Neutrophils + eosinophils
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/Ca
Experimental treatment group (EG):
anti-Gr-1 (late treatment)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (85-90%)
Pathology (EG):
CM (40%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Delayed mortality; Blood: ↓ blood leukocytes; no neutrophils; similar serum TNF-a, IgG and platelet count; Brain: ↓ edema; ↓ monocytes sequestration; ↑ micro-hemorrhages; ↓ injected aggregated albumine; similar platelet sequestration; Lung: ↓ edema; ↓ myeloperoxidase activity (neutrophil enzyme); ↓ monocytes sequestration; similar platelet sequestration; Other organs: no effect on liver pathology; ↑ micro-hemorrhages in skin
Refs:
Senaldi et al., 1994, Infect Immun
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