Molecular group:
Immune cells
Molecule/Cell:
Neutrophils + eosinophils
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/NSlc
Experimental treatment group (EG):
anti-Gr-1 (day - 1)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (10%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (~ 2 weeks); ↓ cerebral hemorrhages; ↓ sequestration of monocytes and pRBCs; similar anemia; PMNs start to increase again 4 days p.i. in peripheral blood; similar TNF-a, IFN-g, IL-10 mRNA and ↓ IL-2, IL-12p40, IL-4 mRNA in the spleen; IL-4 and IL-10 undetectable in brain; no IL-12p40 and ↓ IL-2, IFN-g and TNF-a mRNA in the brain
Refs:
Chen et al., 2000, Clin Exp Immunol
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