Molecular group:
Immune cells
Molecule/Cell:
Monocyte/Macrophages
Plasmodium strain:
Plasmodium berghei K173
pRBC infection titer:
10^3
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
Chemical depletion of macrophages from spleen and liver (early treatment) (lip-Cl2MDP)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (30-40%)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
No cerebral symptoms; no hypothermia
Refs:
Curfs et al., 1993, Parasitology
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