Monocyte/Macrophages

Molecular group: 
Immune cells
Molecule/Cell: 
Monocyte/Macrophages
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^3
Mouse genetic background (Con): 
C57BL/6J
Experimental treatment group (EG): 
Chemical depletion of macrophages from spleen and liver (early treatment) (lip-Cl2MDP)
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (50-75%)
Parasitemia (EG vs Con): 
N.I.
Additional phenotypes (EG vs Con): 
No cerebral symptoms; no hypothermia
Refs: 
Curfs et al., 1993, Parasitology