Molecular group:
Immune cells
Molecule/Cell:
CD1d-restricted NKT cells
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^3 or 10^6 or 10^8
Mouse genetic background (Con):
129/Sv x C57BL/6
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
CD1d -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
Liver pathology
Pathology (EG):
Liver pathology
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Similar liver injury; similar ↑ in hepatic CD3+NK1.1+ and CD3+DX5+ cells; similar cytotoxicity by hepatic lymphocytes (↑ cytotoxicity by DX5+ enriched cells) against hepatocytes was abrogated after depletion of DX5+ lymphocytes (= DX5+CD1d-unresctricted NKT cells)
Refs:
Adachi et al., 2004, Int Immunol
Hyperlink: