CD1d-restricted NKT cells

Molecular group: 
Immune cells
Molecule/Cell: 
CD1d-restricted NKT cells
Plasmodium strain: 
Plasmodium berghei NK65
pRBC infection titer: 
10^3 or 10^6 or 10^8
Mouse genetic background (Con): 
129/Sv x C57BL/6
Level of backcrossing: 
Mixed background (50%)
Experimental treatment group (EG): 
CD1d -/-
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
Liver pathology
Pathology (EG): 
Liver pathology
Parasitemia (EG vs Con): 
N.I.
Additional phenotypes (EG vs Con): 
Similar liver injury; similar ↑ in hepatic CD3+NK1.1+ and CD3+DX5+ cells; similar cytotoxicity by hepatic lymphocytes (↑ cytotoxicity by DX5+ enriched cells) against hepatocytes was abrogated after depletion of DX5+ lymphocytes (= DX5+CD1d-unresctricted NKT cells)
Refs: 
Adachi et al., 2004, Int Immunol