Molecular group:
Immune cells
Molecule/Cell:
NKT cell
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
BALB/c
Level of backcrossing:
Backcrossed for 10 generations
Experimental treatment group (EG):
CD1d -/-
Lethal infection (Con):
N.I.
Lethal infection (EG):
N.I.
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
↓ splenomegaly:↓ BrdU+B220+ cells and similar numbers of CD4+ and CD8+ T cells; ↓ proliferative response after adoptive transfer of B cells from WT mice; ↓ parasite-specific serum IgM, total IgG and IgG1 titers, ↑ IgG2a titers and similar IgG2b and IgG3; similar number of CD69+, B7-1+ and B7-2+B220+ cells in spleen; no downregulation of IFN-g and no switch towards IL-4 production by splenocytes or isolated CD4+ T cells (isolated 7 days p.i.) after in vitro stimulation with anti-CD3; ↓ anti-MSP19 antibody response 7 days after the first infection and 14 days after the second challenge
Refs:
Hansen et al., 2003, Eur J Immunol
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