Molecular group:
Immune cells
Molecule/Cell:
NKT cell
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
BALB/c
Level of backcrossing:
Backcrossed for 10 generations
Experimental treatment group (EG):
CD1d -/-
Lethal infection (Con):
20% (at the end of observation day 18)
Lethal infection (EG):
60% (at the end of observation day 18)
Pathology (Con):
CM (20%)
Pathology (EG):
CM (60%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Developed neurological symptoms; ↑ serum IFN-g and TNF-a; ↑ proliferative response and IFN-g production and similar IL-4 production by CD4+ T cells after in vitro stimulation with parasite lysate at early time-points (day 3); similar proliferative response, no downregulation of IFN-g and no switch towards IL-4 production by splenocytes or isolated CD4+ T cells after in vitro stimulation with anti-CD3 later during infection (day 7)
Refs:
Hansen et al., 2003, Immunity
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