NKT cell

Molecular group: 
Immune cells
Molecule/Cell: 
NKT cell
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
BALB/c
Level of backcrossing: 
Backcrossed for 10 generations
Experimental treatment group (EG): 
CD1d -/-
Lethal infection (Con): 
20% (at the end of observation day 18)
Lethal infection (EG): 
60% (at the end of observation day 18)
Pathology (Con): 
CM (20%)
Pathology (EG): 
CM (60%)
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Developed neurological symptoms; ↑ serum IFN-g and TNF-a; ↑ proliferative response and IFN-g production and similar IL-4 production by CD4+ T cells after in vitro stimulation with parasite lysate at early time-points (day 3); similar proliferative response, no downregulation of IFN-g and no switch towards IL-4 production by splenocytes or isolated CD4+ T cells after in vitro stimulation with anti-CD3 later during infection (day 7)
Refs: 
Hansen et al., 2003, Immunity