Molecular group:
Immune cells
Molecule/Cell:
NK/NKT cells
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
BALB/c
Level of backcrossing:
Backcrossed for 10 generations
Experimental treatment group (EG):
NKC complex C57BL/6 (BALB.B6-Cmv1r)
Lethal infection (Con):
20% (at the end of observation day 17)
Lethal infection (EG):
54% (at the end of observation day 16)
Pathology (Con):
CM (20%)
Pathology (EG):
CM (54%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Sequestration of pRBC and macrophages in cerebral vasculature; ↑ pulmonary edema and anemia; similar serum TNF-a; ↑ serum IFN-g throughout infection and ↓ TGF-b 14 days p.i.; ↑ mRNA expression of IFN-g and IFN-g-inducible genes in spleen (eg. IFN-g inducible GTPases, chemokines,…); ↑ IgM and ↓ IgG (total and parasite specific IgG, IgG1, IgG2a, IgG2b, IgG3) titers during the second week of infection
Refs:
Hansen et al., 2005, Infect Immun
Hyperlink: