Molecular group:
Immune cells
Molecule/Cell:
NK cells
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
2 x 10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
Beige mutation (bg/ bg) (defect in NK cell cytotoxicity)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
More abrupt incline
Additional phenotypes (EG vs Con):
Earlier mortality (~ 1 week)
Refs:
Solomon et al., 1985, Immunol Lett
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