Molecular group:
Immune cells
Molecule/Cell:
NK cells
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-asialo GM1
Lethal infection (Con):
yes
Lethal infection (EG):
80% (at the end of observation day 15)
Pathology (Con):
CM (100%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Increased on day 6
Additional phenotypes (EG vs Con):
Prolonged survival (~ 1 week); similar naïve and activated CD4+ and CD8+ T cells in spleen; ↓ sequestration of CD4+ and CD8+ T cells in the brain; ↓ CXCR3+ T cells in the spleen; ↓ chemotactic response of T cells to IP-10 and T cell migration to the brain could be partially restored by adoptive transfer of IFN-g +/+ NK cells but not by IFN-g -/- NK cells; adoptively transferred IFN-g +/+, but not IFN-g -/- NK cells, were able to migrate into the brain of infected animals
Refs:
Hansen et al., 2007, J Immunol
Hyperlink: