Cytidine deaminase AID (Aicda)/Ig heavy chain µ-secretory domein

Molecular group: 
Immune cells
Molecule/Cell: 
Cytidine deaminase AID (Aicda)/Ig heavy chain µ-secretory domein
Plasmodium strain: 
Plasmodium yoelii 17XNL
pRBC infection titer: 
10^5 - 10^6
Mouse genetic background (Con): 
C57BL/6
Experimental treatment group (EG): 
Aicda -/- (mature B cells which produce IgM, but they cannot undergo isotype switching or secrete Abs)
Lethal infection (Con): 
no
Lethal infection (EG): 
yes (100%)
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
N.I.
Additional phenotypes (EG vs Con): 
Therapeutic blockade of PD-L1 and LAG-3 did not improve parasite clearance
Refs: 
Butler et al., 2012, Nat Immunol