Molecular group:
Immune cells
Molecule/Cell:
B cells/gd T cells
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 10 - 12 generations
Experimental treatment group (EG):
m-BCR -/- (m-MT) + anti-gd TCR
Lethal infection (Con):
no
Lethal infection (EG):
N.I.
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Increased peak and developed a high, persistent parasitemia (around 20%)
Additional phenotypes (EG vs Con):
Anti-gd antibody caused slightly higher peak and significantly higher persistent parasitemia compared to control treated m-MT mice
Refs:
Seixas et al., 1999, J Immunol
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