Molecular group:
Immune cells
Molecule/Cell:
B cells
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 7 - 10 generations
Experimental treatment group (EG):
m-BCR -/- (m-MT)
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Developed a chronic low parasitemia (1-10%)
Additional phenotypes (EG vs Con):
Similar precursor frequencies of CD4+ T cells able to proliferate in response to malarial antigens; CD4+ T cells were still of a predominant IFN-g (Th1) phenotype at the later stages of infection (no switch toward a IL-4 (Th2) phenotype); parasite clearance after adoptive transfer (in the chronic phase) of B cells which restores the Th2 response
Refs:
Langhorne et al., 1998, Proc Natl Acad Sci U S A
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