Molecular group:
Immune cells
Molecule/Cell:
B cells
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 7 generations
Experimental treatment group (EG):
m-BCR -/- (m-MT)
Lethal infection (Con):
no
Lethal infection (EG):
♂ 71 %; ♀ 37 %
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Increased recrudescences and no parasite clearance in 40 days
Additional phenotypes (EG vs Con):
No resistance to a secondary infection; parasite clearance after adoptive transfer (in the chronic phase) of B cells (full clearance) or immune serum (partial clearance) from immune donors; ↑ gd T cells and similar Mac-1+ cells in spleen; gd T cells returned to normal levels after parasite clearance (adoptive transfer of B cells, chloroquine treatment)
Refs:
Von der Weid et al., 1996, J Immunol
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