Molecular group:
Immune cells
Molecule/Cell:
B cells
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 10 - 12 generations
Experimental treatment group (EG):
m-BCR -/- (m-MT)
Lethal infection (Con):
no
Lethal infection (EG):
25%
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Developed a chronic low parasitemia (1-10%)
Additional phenotypes (EG vs Con):
↑ gd T cells in the spleen 35 days p.i.; no ↓ in the % of splenic IFN-g-producing gd T cells 3-4 weeks p.i.; ↓ % of splenic IL-4-producing gd T cells
Refs:
Seixas et al., 1999, J Immunol
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