Molecular group:
Immune cells
Molecule/Cell:
B cells
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 10 generations
Experimental treatment group (EG):
m-BCR -/- (m-MT)
Lethal infection (Con):
no
Lethal infection (EG):
30-40 %
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
No parasite clearance
Additional phenotypes (EG vs Con):
↑ gd T cells and similar Mac-1+ cells in spleen
Refs:
Seixas et al., 2002, Parasite Immunol
Hyperlink: