Molecular group:
Immune cells
Molecule/Cell:
B cells
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
NIH
Experimental treatment group (EG):
anti-m-chain from birth (no B cells)
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Developed a chronic low parasitemia (~1%)
Additional phenotypes (EG vs Con):
No parasite-specific antibodies; no serum antibody of any Ig isotype detected; reconstitution with B cells restored parasite clearance
Refs:
Taylor-Robinson et al., 1996, Infect Immun
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