Molecular group:
Immune cells
Molecule/Cell:
gd T cells
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
129 x C57BL/6
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
d-chain-/- (gd TCR-/-)
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Delayed clearance
Additional phenotypes (EG vs Con):
Similar hypothermia, hypoglycemia and weight loss (slower recovery from weight loss); similar precursor frequency of IFN-g producing CD4+ T cells and ↑ precursor frequency of IL-4 producing CD4+ T cells 31 days p.i. to malaria antigens; earlier ↑ and greater response of CD4+ T cells providing help to B cells; ↑ malaria-specific IgG1, IgG3 and similar IgG2a, IgG2b
Refs:
Seixas et al., 2002, Parasite Immunol
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