Molecular group:
Immune cells
Molecule/Cell:
CD8
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^4
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
anti-CD8 (late treatment)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
MA-ARDS (90%)
Pathology (EG):
Attenuated MA-ARDS
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
↓ lung weight, alveolar edema and cellular infiltration
Refs:
Van den Steen et al., 2010, Am J Crit Care Med
Hyperlink: