Molecular group:
Immune cells
Molecule/Cell:
CD8
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-CD8
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ Evans Blue leakage in brain, lungs, kidneys and heart; ↓ edema in brain, lungs and kidneys; no cracked skull; ↓ serum lactate, HCO3- and glutamate (similar to uninfected mice); ↑ blood pH (similar to normal); similar mean arterial blood flow; ↑ cardiac output (similar to uninfected mice)
Refs:
Chang et al., 2001, Infect Immun
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