Molecular group:
Immune cells
Molecule/Cell:
CD8
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^5
Mouse genetic background (Con):
CBA
Experimental treatment group (EG):
anti-CD8
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (30%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (1-2 weeks) when treated on the onset of CM; stabilization of clinical score; ↓ sequestration of pRBC that are transgenic for a luciferase gene
Refs:
Randall et al., 2008, Infect Immun
Hyperlink: