CD8

Molecular group: 
Immune cells
Molecule/Cell: 
CD8
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^5
Mouse genetic background (Con): 
CBA
Experimental treatment group (EG): 
anti-CD8
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (30%)
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Prolonged survival (1-2 weeks) when treated on the onset of CM; stabilization of clinical score; ↓ sequestration of pRBC that are transgenic for a luciferase gene
Refs: 
Randall et al., 2008, Infect Immun