Molecular group:
Immune cells
Molecule/Cell:
CD8
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^3
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
anti-CD8 (early treatment)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (94%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (1-2 weeks); both early and late (prior to the onset of neurological symptoms) treatment inhibited CM
Refs:
Hermsen et al., 1997, Parasitology
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