Molecular group:
Immune cells
Molecule/Cell:
CD8
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
anti-CD8
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (1-2 weeks); both early and late (prior to the onset of neurological symptoms) treatment inhibited CM
Refs:
Beghdadi et al., 2008, J Exp Med
Hyperlink: