Molecular group:
Immune cells
Molecule/Cell:
CD8+ T cell/CD1d-restricted NKT cells
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^3 or 10^6 or 10^8
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
b2 microglobuline -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
Liver pathology
Pathology (EG):
Liver pathology
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Similar liver injury, serum ALT levels, hepatic DX5+CD3+ cells; similar cytotoxicity by hepatic lymphocytes against hepatocytes
Refs:
Adachi et al., 2004, Int Immunol
Hyperlink: