Molecular group:
Immune cells
Molecule/Cell:
CD4+CD25+Foxp3+ Treg cells
Plasmodium strain:
Plasmodium chabaudi adami DK
pRBC infection titer:
10^5
Mouse genetic background (Con):
BALB/c
Experimental treatment group (EG):
anti-CD25 (day -1 and +1)
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↑ CD4+FOXP3-CD69+, ↓ CD4+FOXP3-CD25+ and similar CD4-CD69+ lymphocytes in spleen; ↑ parasite-specific IL-2 and similar IFN-g response by CD4+ T cells (in vitro); ↑ IFN-g and similar IL-2 response by CD4+ T cells after stimulation with anti-CD3 (in vitro); similar TNF-a, IFN-g and ↑ IL-10 production by unstimulated CD90- (Thy-1-) splenocytes and ↑ IFN-g prodyction by unstimulated CD4+ cells (in vitro); ↑ anemia
Refs:
Cambos et al., 2008, Int J Parasitol
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