Molecular group:
Immune cells
Molecule/Cell:
CD4+CD25+Foxp3+ Treg cells
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-CD25 (day 4)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (80 %)
Pathology (EG):
CM (20%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Therapeutic potential of anti-CD25 treatment was lost when initiated after the onset of neurological symptoms
Refs:
Amante et al., 2007, Am J Pathol
Hyperlink: