CD4+CD25+Foxp3+ Treg cells

Molecular group: 
Immune cells
Molecule/Cell: 
CD4+CD25+Foxp3+ Treg cells
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^5
Mouse genetic background (Con): 
C57BL/6
Experimental treatment group (EG): 
anti-CD25 (day -14)
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (10%)
Parasitemia (EG vs Con): 
Reduced total parasite burden
Additional phenotypes (EG vs Con): 
Prolonged survival (2 weeks); no neurological symptoms
Refs: 
Randall et al., 2008, Infect Immun