Molecular group:
Immune cells
Molecule/Cell:
CD4+CD25+Foxp3+ Treg cells
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-CD25 (day -14)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (10%)
Parasitemia (EG vs Con):
Reduced total parasite burden
Additional phenotypes (EG vs Con):
Prolonged survival (2 weeks); no neurological symptoms
Refs:
Randall et al., 2008, Infect Immun
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