Molecular group:
Immune cells
Molecule/Cell:
CD4+CD25+Foxp3+ Treg cells
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-CD25 (day -1)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (90%)
Pathology (EG):
CM (20%)
Parasitemia (EG vs Con):
Reduced on days 5-7
Additional phenotypes (EG vs Con):
similar results as with anti-CD25 treatment 1 day before infection (see above), thus the protective effect is probably mediated by natural Treg cells and not by inducible Treg cells (although the latter might contribute as well)
Refs:
Amante et al., 2007, Am J Pathol
Hyperlink: