CD4+CD25+Foxp3+ Treg cells

Molecular group: 
Immune cells
Molecule/Cell: 
CD4+CD25+Foxp3+ Treg cells
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^5
Mouse genetic background (Con): 
C57BL/6
Experimental treatment group (EG): 
anti-CD25 (day -1)
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (90%)
Pathology (EG): 
CM (20%)
Parasitemia (EG vs Con): 
Reduced on days 5-7
Additional phenotypes (EG vs Con): 
similar results as with anti-CD25 treatment 1 day before infection (see above), thus the protective effect is probably mediated by natural Treg cells and not by inducible Treg cells (although the latter might contribute as well)
Refs: 
Amante et al., 2007, Am J Pathol