Molecular group:
Immune cells
Molecule/Cell:
CD4+CD25+Foxp3+ Treg cells
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-CD25 (day - 1 and day 1)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (80%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Increased on day 7
Additional phenotypes (EG vs Con):
Inactivation of both regulatory and effector T cells
Refs:
Vigário et al., 2007, Int J Parasitology
Hyperlink: