Molecular group:
Immune cells
Molecule/Cell:
MHC-II/IP-10
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 10 generations
Experimental treatment group (EG):
IA-b -/- (↓MHC-II → ↓ CD4) + anti-IP-10
Lethal infection (Con):
N.I.
Lethal infection (EG):
N.I.
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar on day 5
Additional phenotypes (EG vs Con):
Prolonged survival (days)
Refs:
Nie et al., 2009, PLoS Pathog
Hyperlink: