MHC-II

Molecular group: 
Immune cells
Molecule/Cell: 
MHC-II
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6 x 129
Level of backcrossing: 
Mixed background (50%)
Experimental treatment group (EG): 
A -/- or Ii -/- (↓MHC-II → ↓ CD4)
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (84%)
Pathology (EG): 
CM (44%)
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Similar hematocrit levels and neurological symptoms
Refs: 
Yañez et al., 1996, J Immunol