Molecular group:
Immune cells
Molecule/Cell:
MHC-II
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6 x 129
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
A -/- or Ii -/- (↓MHC-II → ↓ CD4)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (84%)
Pathology (EG):
CM (44%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar hematocrit levels and neurological symptoms
Refs:
Yañez et al., 1996, J Immunol
Hyperlink: