Molecular group:
Immune cells
Molecule/Cell:
CD4
Plasmodium strain:
Plasmodium yoelii 17XNL
pRBC infection titer:
10^5 - 10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-CD4
Lethal infection (Con):
no
Lethal infection (EG):
yes (100%)
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Additional therapeutic blockade of PD-L1 and LAG-3 did not improve parasite clearance
Refs:
Butler et al., 2012, Nat Immunol
Hyperlink: