Molecular group:
Immune cells
Molecule/Cell:
CD4
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/J, CBA/Ca
Experimental treatment group (EG):
anti-CD4
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (79%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
No neurological symptoms; prolonged survival (~ 2 weeks); ↓ serum TNF-a
Refs:
Grau et al., 1987, Science
Hyperlink: