Molecular group:
Immune cells
Molecule/Cell:
CD4
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
5 x 10^3 trophozoites
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-CD4
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Increased peak and developed a high, persistent parasitemia
Additional phenotypes (EG vs Con):
Similar parasite-specific IgM early during infection and no IgG; high, persistent parasitemia coincided with the high level of reticulocytosis
Refs:
Süss et al., 1988, Infect Immun
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