Molecular group:
Immune cells
Molecule/Cell:
T cells
Plasmodium strain:
Plasmodium yoelii 17XNL
pRBC infection titer:
10^5 or 10^6
Mouse genetic background (Con):
BALB/cAnN
Level of backcrossing:
♂ Backcrossed for at least 10 generations; ♀ Backcrossed for 3 generations
Experimental treatment group (EG):
Nude mice (nu/nu): no thymus thus no mature T cells
Lethal infection (Con):
no
Lethal infection (EG):
yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Increased without clearance
Additional phenotypes (EG vs Con):
Thymus grafting from birth protected nude mice from a lethal infection; ↑ IgG1, IgG2 and similar IgM levels before and after infection
Refs:
Weinbaum et al., 1976, J Immunol
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