Molecular group:
Immune cells
Molecule/Cell:
T cells
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
NIH, thymectomy + anti-CD4
Experimental treatment group (EG):
TH1 cells from infected mice + NOS inhibitor
Lethal infection (Con):
75-100%
Lethal infection (EG):
75-100%
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar (No NO3- in serum during peak parasitemia); increase in IgG2a levels abrogated compared to Th1 reconstituted mice without NOS inhibitor; IgM not affected by NOS inhibitor
Refs:
Taylor-Robinson et al., 1993, Science
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