Molecular group:
Immune cells
Molecule/Cell:
T cells
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
NIH, thymectomy + anti-CD4
Experimental treatment group (EG):
TH1 cells from infected mice
Lethal infection (Con):
75-100%
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar peak, parasite clearance after 1 recrudescence
Additional phenotypes (EG vs Con):
↑ serum NO3- during peak parasitemia; ↑ IgM; detection of IgG2a during peak and recrudescent parasitemia; anti-IgG treatment ↑ recrudescent parasitemia
Refs:
Taylor-Robinson et al., 1993, Science
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