Molecular group:
Immune cells
Molecule/Cell:
T cells
Plasmodium strain:
Plasmodium yoelii 17XNL
pRBC infection titer:
10^4 en 10^6
Mouse genetic background (Con):
BALB/c-nu/+
Level of backcrossing:
N.I.
Experimental treatment group (EG):
Nude mice (nu/nu): no thymus thus no mature T cells
Lethal infection (Con):
no
Lethal infection (EG):
yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
↓ IFN-g and similar IL-4 and TNF-a protein levels in the spleen 24h p.i.; ↑ parasite inoculum was necessary to induce IFN-g production in spleen
Refs:
De Souza et al., 1997, Infect Immun
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