Molecular group:
Immune cells
Molecule/Cell:
T cells
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/J, CBA/Ca
Experimental treatment group (EG):
AT x BM (no thymus: no mature T cells)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (90%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ serum IgM and IgG; protection was abrogated after reconstitution with CD4+ T cells (partially restored IgM + IgG levels), but not after reconstitution with CD8+ T cells
Refs:
Grau et al., 1986, J Immunol
Hyperlink: