Molecular group:
Immune cells
Molecule/Cell:
Lymphocytes
Plasmodium strain:
Plasmodium chabaudi adami 556KA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6J x 129
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
JH-gene segment -/- (JHD -/-)
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Slightly delayed and developed a chronic, low parasitemia
Additional phenotypes (EG vs Con):
↑ gd T cells (mostly CD4-CD8-) and similar numbers of ab T cells in spleen; ↑ gd T cells and similar ab T cells in cell-cycle during acute parasitemia (determines the proliferative response); treatment with immune serum ↓ parasitemia
Refs:
Van der heyde et al., 1996, J Leukoc Biol
Hyperlink: