Molecular group:
Immune cells
Molecule/Cell:
Lymphocytes
Plasmodium strain:
Plasmodium chabaudi adami 556KA
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6 x CBA
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
anti-m-chain from birth (no B cells)
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Developed a chronic low parasitemia
Additional phenotypes (EG vs Con):
Resistant to a secondary infection with P. chabaudi adami 556 KA or P. vinckei, but not to P. yoelii 17XNL or P. berghei
Refs:
Grun et al., 1981, Nature
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