Molecular group:
Immune cells
Molecule/Cell:
Lymphocytes
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^4
Mouse genetic background (Con):
MF1
Level of backcrossing:
N.I.
Experimental treatment group (EG):
RAG2 -/- (no mature T/B cells)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (60-80%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
similar
Additional phenotypes (EG vs Con):
Prolonged survival (> 30 days); no neurological symptoms
Refs:
Miyakoda et al., 2008, J Immunol
Hyperlink: