C5

Molecular group: 
Complement
Molecule/Cell: 
C5
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
5 x 10^5
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
Backcrossed for 8 generations
Experimental treatment group (EG): 
C5 -/-
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (<10%)
Parasitemia (EG vs Con): 
N.I.
Additional phenotypes (EG vs Con): 
↓ serum TNF and IL-6; ↓ brain CD8+ T cells
Refs: 
Ramos et al., 2011, J Immunol