Molecular group:
Complement
Molecule/Cell:
C5
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 8 generations
Experimental treatment group (EG):
C5 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (<10%)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
↓ serum TNF and IL-6; ↓ brain CD8+ T cells
Refs:
Ramos et al., 2011, J Immunol
Hyperlink: