Molecular group:
Complement
Molecule/Cell:
C5a
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^5
Mouse genetic background (Con):
A/J
Experimental treatment group (EG):
12.5% DNA from C57BL/6 mice (including the C5 WT gene) (= AcB55)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
Delayed CM
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Accelerated development of CM
Refs:
Patel et al., 2008, J Exp Med
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