Molecular group:
Complement
Molecule/Cell:
C5a
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^5
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
12.5% DNA from A/J mice (including the C5 mutant gene) (= BcA76)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (90%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Slightly reduced CM incidence and survival
Refs:
Patel et al., 2008, J Exp Med
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