Molecular group:
Complement
Molecule/Cell:
C1q
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
129/Sv
Level of backcrossing:
Pure strain (100%)
Experimental treatment group (EG):
C1qa -/-
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Slightly delayed and slightly increased peak
Additional phenotypes (EG vs Con):
↑ parasitemia during secondary infection; similar Ab responses during primary infection; ↓ parasite-spec IgG2a 100 days p.i.; ↑ parasite-spec IgM and IgG2a after second challenge (120 days p.i.); ↑serum IFN-g 5, 7 and 9 days p.i.; no difference in IFN-g and IL-4 producing CD4+ T cells or precursor frequenties
Refs:
Taylor et al., 2001, Infect Immun
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